FluidFM® publications
From nano-injection into single-cells to material sciences with one patented technology
Since its invention in 2009, FluidFM technology facilitates cutting-edge research results in biophysics, mechanobiology, life sciences and nanotechnology.
Below we list the publications, where FluidFM was used by the scientific community, as well as reviews where FluidFM was prominently covered. Explore 100+ publications with 8+ Ø impact factor, divided to four categories based on the FluidFM modes.
MAIN PUBLICATION / FluidFM TECHNOLOGY INTRODUCTION
A. Meister, M. Gabi, P. Behr, P. Studer, J. Vörös, P. Niedermann, J. Bitterli, J. Polesel-Maris, M. Liley, H. Heinzelmann & T. Zambelli.
FluidFM: Combining atomic force microscopy and nanofluidics in a universal liquid delivery system for single cell applications and beyond.
(2009) Nano Letters, 9(6), 2501-2507.
Injection & Sampling
Dispensing & Nanoprinting
2024
Giger, G. H., Ernst, C., Richter, I., Gassler, T., Field, C. M., Sintsova, A., Kiefer, P., Gäbelein, C. G., Guillaume–Gentil, O., Scherlach, K., Bortfeld-Miller, M., Zambelli, T., Sunagawa, S., Künzler, M., Hertweck, C., & Vorholt, J. A. (2024). Inducing novel endosymbioses by implanting bacteria in fungi. (2024) Nature.
Injection & Sampling
Antony JS, Herranz AM, Mohammadian Gol T, Mailand S, Monnier P, Rottenberger J, Roig-Merino A, Keller B, Gowin C, Milla M, Beyer TA, Mezger M. "Accelerated generation of gene‐engineered monoclonal CHO cell lines using FluidFM nanoinjection and CRISPR/Cas9." (2024) Biotechnology Journal.
Injection & Sampling
Ernst, Chantal, Patrick R. Andreassen, Gabriel H. Giger, Bidong D. Nguyen, Christoph G. Gäbelein, Orane Guillaume-Gentil, Stefan A. Fattinger, Mikael E. Sellin, Wolf-Dietrich Hardt, and Julia A. Vorholt. "Direct Salmonella injection into enteroid cells allows the study of host–pathogen interactions in the cytosol with high spatiotemporal resolution." (2024) Plos Biology.
Injection & Sampling
2023
Kovács, Kinga Dóra, Visnovitz, Tamás, Gerecsei, Tamás, Peter, Beatrix, Kurunczi, Sándor, Koncz, Anna, Németh, Krisztina, Lenzinger, Dorina, Vukman, Krisztina V., Balogh, Anna, Rajmon, Imola, Lőrincz, Péter. Székács, Inna, Buzás, Edit I., Horvath, Robert, Nanoinjection of extracellular vesicles to single live cells by robotic fluidic force microscopy, (2023) Journal of Extracellular Vesicles.
Injection & Sampling
2022
W. Chen, O. Guillaume-Gentil, P. Y. Rainer, C. G. Gäbelein, W. Saelens, V. Gardeaux, A. Klaeger, R. Dainese, M. Zachara, T. Zambelli, J. A. Vorholt & B. Deplancke. Live-seq enables temporal transcriptomic recording of single cells. (2022) Nature
Injection & Sampling
Q. Hu, J. Lu, X. Zhang, R. Liu & S-H. Yang. Mitochondria transplantation/transfer between single cells. (2022). Journal of Cerebral Blood Flow & Metabolism.
Injection & Sampling
C. Gäbelein, Q. Feng, E. Sarajlic, T. Zambelli, O. Guillaume-Gentil, B. Kornmann & J. Vorholt. Mitochondria transplantation between living cells. (2022). PLoS Biology.
Injection & Sampling
O. Guillaume-Gentil, C. G. Gäbelein, S. Schmieder, V. Martinez, T. Zambelli, M. Künzler & J.A. Vorholt. Injection into and extraction from single fungal cells. (2022). Communications Biology.
Injection & Sampling
2021
Research Square.C.G. Gäbelein. Single cell engineering using fluidic force microscopy. (2021). PhD thesis.
Injection & Sampling
W. Chen, O. Guillaume-Gentil, R. Dainese, P. Rainer, M. Zachara, C. Gäbelein, J. Vorholt & B. Deplancke. Genome-wide molecular recording using Live-seq. (2021). BioRxiv.
Injection & Sampling
E. Zare-Eelanjegh, I. Luchtefeld, M. Li, E. Sarajilic & T. Zambelli. Fluidic force microscopy for monitoring and quantifying the nucleo-cytoskeletal coupling. (2021). European Biophysics Journal with Biophysics Letters.
Injection & Sampling
M. Li, L. Liu & T. Zambelli. FluidFM for single-cell biophysics. (2021). Nano Research. doi: 10.1007/s12274-021-3573-y
FluidFM for single-cell biophysics
(2021) Nano Research.
Injection & Sampling
Pick & Place
Y. Cui, X. Lyu, L. Ding, L. Ke, D. Yang, M. Pirouz, Y. Qi, J. Ong, G. Gao, P. Du & R.I. Gregory. Global miRNA dosage control of embryonic germ layer specification. (2021) Nature.
Injection & Sampling
2020
P. Saha, T. Duanis-Assaf & M. Reches. Fundamentals and Applications of FluidFM Technology in Single-Cell Studies. (2020) Advanced Materials Interfaces.
Injection & Sampling
Localized Dispensing
Pick & Place
2018
P. Roder. Combination of fluorescence microscopy and atomic force microscopy for the investigation of physiological processes in living cells. (Thesis) (2018) Universität Potsdam.
Injection & Sampling
Localized Dispensing
Y. Wei & Q. Xu. A Survey of Force-Assisted Robotic Cell Microinjection Technologies. (2018) IEEE Transactions on Automation Science and Engineering, 1-15.
Injection & Sampling
H. M. Grandin, O. Guillaume-Gentil, T. Zambelli, M. Mayer, J. Houghtaling, C. G. Palivan, M. Textor, & F. Höök. Bioinspired, nanoscale approaches in contemporary bioanalytics (Review). (2018) Biointerphases 13, 040801.
Injection & Sampling
Localized Dispensing
Pick & Place
M. Y. Amarouch, J. E. Hilaly & D. Mazouzi. AFM and FluidFM Technologies: Recent Applications in Molecular and Cellular Biology. Scanning, Volume 2018, Article ID 7801274, 10 pages.
Injection & Sampling
Localized Dispensing
Pick & Place
P. Frederix, P. Werten & D. Yablon. FluidFM: Precise fluidic positioning and delivery platform with applications in cell biology and soft matter. (2018) Microscopy and Analysis, John Wiley & Sons Ltd.
Injection & Sampling
Localized Dispensing
Pick & Place
O. Guillaume-Gentil, M. Mittelviefhaus, L. Dorwling-Carter, T. Zambelli & J. A. Vorholt. FluidFM Applications in Single-Cell Biology. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Implementations, Applications (Chapter 15), 2018, Wiley-VCH Verlag GmbH & Co.
Injection & Sampling
Localized Dispensing
Pick & Place
2017
S. G. Higgins, M. M. Stevens. Extracting the contents of living cells – Alumnia “nanostraws” enable longitudinal intracellular monitoring of live cells. (April 2017) Science, 356(6336).
Injection & Sampling
O. Guillaume-Gentil, T. Rey, P. Kiefer, A.J. Ibáñez, R. Steinhoff, R. Brönnimann, L. Dorwling-Carter, T. Zambelli, R. Zenobi & J.A. Vorholt. Single-Cell Mass Spectrometry of Metabolites Extracted from Live Cells by Fluidic Force Microscopy. (May 2017) Anal Chem., 89(9), 5017-5023.
Injection & Sampling
2016
O. Guillaume-Gentil, R.V. Grindberg, R. Kooger, L. Dorwling-Carter, V. Martinez, D. Ossola, M. Pilhofer, T. Zambelli & J.A. Vorholt. Tunable Single-Cell Extraction for Molecular Analyses. (Jul 2016) Cell, 166(2), 506-516.
Injection & Sampling
2015
P. Behr. FluidFM: Combining AFM with Micro-fluidics for Applications in Lifesciences and Multiparameter Surface Characterization. (Thesis) (2015) ETH Zurich.
Injection & Sampling
Localized Dispensing
Pick & Place
2014
O. Guillaume-Gentil, E. Potthoff, D. Ossola, C.M. Franz, T. Zambelli & J.A. Vorholt. Force-controlled manipulation of single cells: From AFM to FluidFM. Trends in Biotechnology. Elsevier Ltd.
Injection & Sampling
Localized Dispensing
Pick & Place
2013
P. Dörig. Manipulating cells and colloids with FluidFM. (Thesis) (2013) ETH Zurich.
Injection & Sampling
Localized Dispensing
Pick & Place
O. Guillaume-Gentil, E. Potthoff, D. Ossola, P. Dörig, T. Zambelli & J.A. Vorholt. Force-controlled fluidic injection into single cell nuclei. Small, 9(11), 1904 — 1907.
Injection & Sampling
2009
A. Meister, M. Gabi, P. Behr, P. Studer, J. Vörös, P. Niedermann, J. Bitterli, J. Polesel - Maris, M. Liley, H. Heinzelmann & T. Zambelli. FluidFM: Combining atomic force microscopy and nanofluidics in an universal liquid delivery system for single cell applications and beyond. (2009) Nano Letters, 9 (6), 2501–2507.
Injection & Sampling
Localized Dispensing
2024
Yang Y, Wen D, Lin F, Song X, Pang R, Sun W, Yu D, Zhang Z, Yu T, Kong J, Zhang L, Cao X, Liao W, Wang D, Yang Q, Liang J, Zhang N, Li K, Xiong C, Liu Y. (2024) Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors. Science Advances.
OthersHuang Y, Celik U, Xu Z, Speer D, Ossola D, Faller R, Parikh AN, Liu G-Y. (2024) Controlled Assembly of Lipid Molecules via Regulating Transient Spatial Confinement. Chemistry.
Dispensing & NanoprintingLiu X, Min Q, Cheng X, Zhang W, Wu Q, Chen X, Lv M, Liu S, Zhao H, Yang D, Tai Y, Lei X, Wang Y, Zhan Q. (2024) Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits. British Journal of Cancer.
OthersGiger, G. H., Ernst, C., Richter, I., Gassler, T., Field, C. M., Sintsova, A., Kiefer, P., Gäbelein, C. G., Guillaume–Gentil, O., Scherlach, K., Bortfeld-Miller, M., Zambelli, T., Sunagawa, S., Künzler, M., Hertweck, C., & Vorholt, J. A. (2024). Inducing novel endosymbioses by implanting bacteria in fungi. Nature.
Injection & SamplingYan G, Li Y, Wang H, Cui S, Li Y, Zhang L, Yan J. Multiscale approach to the characterization of the interfacial properties of micellar casein and whey protein blends and their effects on recombined dairy creams. (2024) Food Research International.
OthersZhang X, Burattini M, Duru J, Chala N, Wyssen N, Cofiño-Fabres C, Rivera-Arbeláez JM, Passier R, Poulikakos D, Ferrari A, Tringides C, Vörös J, Luciani GB, Miragoli M, Zambelli T. Multimodal Mapping of Electrical and Mechanical Latency of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Layers. (2024) ACS Nano.
OthersLüchtefeld I, Pivkin IV, Gardini L, Zare-Eelanjegh E, Gäbelein C, Ihle SJ, Reichmuth AM, Capitanio M, Martinac B, Zambelli T, Vassalli M. Dissecting cell membrane tension dynamics and its effect on Piezo1-mediated cellular mechanosensitivity using force-controlled nanopipettes. (2024). Nature Methods.
OthersWang X, Xu H, Ning F, Duan S, Hu Y, Ding X, Xu FJ. Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films. (2024). Macromolecular Rapid Communications.
OthersMüller-Renno C, Ziegler C. The Contribution of Scanning Force Microscopy on Dental Research: A Narrative Review. (2024). Materials.
OthersAntony JS, Herranz AM, Mohammadian Gol T, Mailand S, Monnier P, Rottenberger J, Roig-Merino A, Keller B, Gowin C, Milla M, Beyer TA, Mezger M. "Accelerated generation of gene‐engineered monoclonal CHO cell lines using FluidFM nanoinjection and CRISPR/Cas9." (2024) Biotechnology Journal.
Injection & SamplingErnst, Chantal, Patrick R. Andreassen, Gabriel H. Giger, Bidong D. Nguyen, Christoph G. Gäbelein, Orane Guillaume-Gentil, Stefan A. Fattinger, Mikael E. Sellin, Wolf-Dietrich Hardt, and Julia A. Vorholt. "Direct Salmonella injection into enteroid cells allows the study of host–pathogen interactions in the cytosol with high spatiotemporal resolution." (2024) Plos Biology.
Injection & SamplingBuisson, J., Zhang, X., Zambelli, T., Lavalle, P., Vautier, D., & Rabineau, M. Reverse Mechanotransduction: Driving Chromatin Compaction to Decompaction Increases Cell Adhesion Strength and Contractility. (2024) Nano Letters.
OthersGunaratnam, G., Leisering, R., Wieland, B., Dudek, J., Miosge, N., Becker, S. L., & Jung, P. Characterization of a unique attachment organelle: Single-cell force spectroscopy of Giardia duodenalis trophozoites. (2024) Nanoscale.
OthersTufoni, C., Battistella, A., Luppi, S., Boscolo, R., Ricci, G., Lazzarino, M., & Andolfi, L. Flagellar beating forces of human spermatozoa with different motility behaviors. (2024) Reproductive Biology and Endocrinology.
OthersBonyár, A., Nagy, Á. G., Gunstheimer, H., Fläschner, G., & Horvath, R. Hydrodynamic function and spring constant calibration of FluidFM micropipette cantilevers. (2024) Microsystems & Nanoengineering.
OthersHabli, Z., Lahoud, R., Zantout, A., Abou-Kheir, W., & Khraiche, M. L. Single-cell fluid-based force spectroscopy reveals near lipid size nano-topography effects on neural cell adhesion. (2024) Lab on a Chip.
OthersMulder, E. J., Moser, B., Delgado, J., Steinhardt, R. C., & Esser-Kahn, A. P. Evidence of collective influence in innate sensing using fluidic force microscopy. (2024) Frontiers in Immunology.
Dispensing & Nanoprinting2023
Z. Yang, X. Zhang, H. Li, B. Zhu, K. Feng and R. Wang, Impact of Dynamic Tip-Surface Interactions on Microdroplet Formation via Fluid Force Microscopy, (2023) IEEE Transactions on Nanotechnology.
OthersXiaoxuan Zhang, Martin Fussenegger, Structural materials meet synthetic biology in biomedical applications, (2023) Materials Today.
OthersRosales, Abigail Burato, Causserand, Christel, Coetsier, Clémence, Formosa-Dague, Cécile, Probing the reduction of adhesion forces between biofilms and anti-biofouling filtration membrane surfaces using FluidFM technology, (2023) Colloids and Surfaces B: Biointerfaces.
OthersBattistella, A., Andolfi, L., Stebel, M., Ciubotaru, C., & Lazzarino, M. Investigation on the change of spermatozoa flagellar beating forces before and after capacitation. (2023) Biomaterials Advances, 145.
Pick & Place Kovács, Kinga Dóra, Visnovitz, Tamás, Gerecsei, Tamás, Peter, Beatrix, Kurunczi, Sándor, Koncz, Anna, Németh, Krisztina, Lenzinger, Dorina, Vukman, Krisztina V., Balogh, Anna, Rajmon, Imola, Lőrincz, Péter. Székács, Inna, Buzás, Edit I., Horvath, Robert, Nanoinjection of extracellular vesicles to single live cells by robotic fluidic force microscopy, (2023) Journal of Extracellular Vesicles.
Injection & Sampling Xu, H., Duan, S., Hu, Y., Ding, X., & Xu, F.-J. Rapid Regulation of Cardiomyocytes Adhesion on Substrates with Varied Modulus via Mechanical Cues. (2023) Biomacromolecules.
OthersM. Menetrey, C. van Nisselroy, M. Xu, J. Hengsteler, R. Spolenak & T. Zambelli . Microstructure-driven electrical conductivity optimization in additively manufactured microscale copper interconnects. (2023) RSC Advances.
Pick & Place N. Chala, X. Zhang, T. Zambelli, Z. Zhang, T. Schneider, D. Panozzo, D. Poulikakos & A. Ferrari. 4D Force Detection of Cell Adhesion and Contractility. (2023) Nano Letters.
Pick & Place 2022
A. Battistella, L. Andolfi, M. Stebel, C. Ciubotaru & M.Lazzarino. Investigation on the change of spermatozoa flagellar beating forces before and after capacitation. (2022) Biomaterials Advances.
Pick & Place
L. Angeloni, B. Popa, M. Nouri-Goushki, M. Minneboo, A. A. Zadpoor, M. K. Ghatkesar & L. E. Fratila-Apachitei. Fluidic Force Microscopy and Atomic Force Microscopy Unveil New Insights into the Interactions of Preosteoblasts with 3D-Printed Submicron Patterns. (2022) Small.
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W. Chen, O. Guillaume-Gentil, P. Y. Rainer, C. G. Gäbelein, W. Saelens, V. Gardeaux, A. Klaeger, R. Dainese, M. Zachara, T. Zambelli, J. A. Vorholt & B. Deplancke. Live-seq enables temporal transcriptomic recording of single cells. (2022) Nature.
Injection & Sampling
Q. Hu, J. Lu, X. Zhang, R. Liu & S-H. Yang. Mitochondria transplantation/transfer between single cells. (2022). Journal of Cerebral Blood Flow & Metabolism.
Injection & Sampling
F. Weigl, C. Blum, A. Sancho & J. Groll. Correlative Analysis of Intra- versus Extracellular Cell Detachment Events via the Alignment of Optical Imaging and Detachment Force Quantification. (2022). Adv. Mater. Technol.
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Y. Qiu, C. Chien, B. Maroulis, J. Bei, A. Gaitas & B. Gong. Extending applications of AFM to fluidic AFM in single living cell studies. (2022). Journal of Cellular Physiology.
Others
B.S. Harris, Y. Huang, A. Karsai, W. Su, P.D. Sambre, A.N. Parikh, G. Liu & R. Faller. Impact of Surface Polarity on Lipid Assembly under Spatial Confinement. (2022). Langmuir.
Dispensing & Nanoprinting
D. Lee, Y. Woo, J. Lim, I. Park, S.K. Park & J.W. Park. Quantification of a Neurological Protein in a Single Cell without Amplification. (2022). ACS Omega.
Dispensing & Nanoprinting
G. Apte, M. Hirtz & T. Nguyen. FluidFM-Based Fabrication of Nanopatterns: Promising Surfaces for Platelet Storage Application. (2022). ACS App. Mater. Interfaces.
Dispensing & Nanoprinting
P.W. Doll, K. Doll, A. Winkel, R. Thelen, R. Ahrens, M. Stiesch & A.E. Guber. Influence of the Available Surface Area and Cell Elasticity on Bacterial Adhesion Forces on Highly Ordered Silicon Nanopillars. (2022). ACS Omega.
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A.G. Nagy, N. Kanyó, A. Vörös, I. Székács, A. Bonyár & R. Horvath. Population distributions of single-cell adhesion parameters during the cell cycle from high-throughput robotic fluidic force microscopy. (2022). Scientific Reports.
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E. Berganza, G. Apte, S.K, Vasantham, T. Nguyen & M. Hirtz. Integration of Biofunctional Molecules into 3D-Printed Polymeric Micro-/Nanostructures. (2022). Polymers.
Dispensing & Nanoprinting
F. Pan, M. Liu, S. Altenried, M. Lei, J. Yang, H. Straub, W.W. Schmal, K. Maniura-Weber, O. Guillaume-Gentil & Q. Ren. Uncoupling bacterial attachment on and detachment from polydimethylsiloxane surfaces though empirical and simulation studies. (2022). Journal of Colloid and Interface Science.
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T.G. Pattinson, S. Wang, R.D. Miller, G. Liu & G.G. Qiao. 3D nanoprinting via spatially controlled assembly and polymerization. (2022). Nat Commun.
Dispensing & Nanoprinting
C. Gäbelein, Q. Feng, E. Sarajlic, T. Zambelli, O. Guillaume-Gentil, B. Kornmann & J. Vorholt. Mitochondria transplantation between living cells. (2022). PLoS Biology.
Injection & Sampling
C. Shen, Z. Zhu, D. Zhu, C. van Nisselroy, T. Zambelli & D. Momotenko. Electrochemical 3D printing of Ni-Mn and Ni-Co alloy with FluidFM. (2022). Nanotechnology.
Dispensing & Nanoprinting
O. Guillaume-Gentil, C. G. Gäbelein, S. Schmieder, V. Martinez, T. Zambelli, M. Künzler & J.A. Vorholt. Injection into and extraction from single fungal cells. (2022). Communications Biology.
Injection & Sampling
C. Chien, J. Jiang, B. Gong, T. Li & A. Gaitas. AFM Microfluidic Cantilevers as Weight Sensors for Single Cell Mass Measurements. (2022). BioRxiv.
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Others
A. Sancho, M. B. Taskin, L. Wistlich, P. Stahlhut, K. Wittmann, A. Rossi & J. Groll. Cell Adhesion Assessment Reveals a Higher Force per Contact Area on Fibrous Structures Compared to Flat Surfaces. (2022). ACS Biomater. Sci. Eng.
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2021
Research Square.C.G. Gäbelein. Single cell engineering using fluidic force microscopy. (2021). PhD thesis.
Injection & Sampling
Y. Qiu, C. Chien, B. Maroulis, A. Gaitas & B. Gong. Extending applications of AFM to fluidic AFM in single living cell and extracellular vesicle studies. (2021). Research Square.
Others
A. Nagy, R. Horvath, A. Bonyár & M. Sztilkovics. A custom Software for the Evaluation of Single-Cell Force-Spectroscopy Data Acquired by FluidFM BOT. (2021). IEEE Xplore.
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Others
M.I. Rahim, K. Doll. N.S. Stumpp, M. Eisenburger & M. Stiesch. Multilayered Adsorption of Commensal Microflora on Implant Surfaces: an Unconventional and Innovative Method to Prevent Bacterial Infections Associated with Biomaterials. (2021). Adv. Mater. Interfaces.
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G. Gunaratnam, J. Dudek, P. Jung, S. Becker, K. Jacobs, M. Bischoff & M. Hannig. Quantification of the Adhesion Strength of Candida albicans to Tooth Enamel. (2021). Microorganisms.
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E. Berganza & M. Hirtz. Direct-Write Patterning of Biomimetic Lipid Membranes In Situ with FluidFM. (2021). ACS Appl. Mater. Interfaces.
Dispensing & Nanoprinting
E. Zare-Eelanjegh, I. Luchtefeld, M. Li, E. Sarajilic & T. Zambelli. Fluidic force microscopy for monitoring and quantifying the nucleo-cytoskeletal coupling. (2021). European Biophysics Journal with Biophysics Letters.
Injection & Sampling
J. Yang, J. Park, M. Koehler, J. Simpson, D. Luque, J.M. Rodriguez & D. Alsteens. Rotavirus Binding to Cell Surface Receptors Directly recruiting a-integrin. (2021). Advanced Nanobiomed Research.
Others
I. Demi, I. Lüchtefeld, C. Lemen, E. Dague, P. Guiraud, T. Zambelli & C. Formosa-Dague. Probing the interactions between air bubbles and (bio)interfaces at the nanoscale using FluidFM technology. (2021). Journal of Colloid and Interface Science.
Dispensing & Nanoprinting
C. Müller-Renno, D. Remmel, M. Braun, K. Boonrod, G. Krczal & C. Ziegler. Producing plant virus patterns with defined 2D structure. (2021). PSS Applications and materials science.
Dispensing & Nanoprinting
Á. Gábor Nagy, N. Pap, R. Horvath & A. Bonyár. Determination of the Resonance Frequency and Spring Constant of FluidFM Cantilevers with Numerical Simulations. (2021) ISSE.
Others
W. Li, A. Sancho, W. Chung, Y. Vinik, J. Groll, Y. Zick, O. Medalia, A.D. Bershadsky & B. Geiger. Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates. (2021) Journal of Cell Science.
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A. Garitano-Trojaola, A. Sancho, R. Goetz, P. Eiring, S. Walz, H. Jetani, J. Gil-Pulido, M. DaVia, E. Teufel, N. Rhodes, L. Haertle, E. Arellano-Viera, R. Tibes, A. Rosenwald, L. Rasche, M. Hudecek, M. Sauer, J. Groll, H. Einsele, S. Kraus & M. Kortüm. Actin cytoskeleton deregulaltion confers midostaurin resistance in FLT-3 mutant acute myeloid leukemia.
(2021) Communications Biology.
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S. Wang, S. Liu, A. Sulkanen, J.M. Fox, X. Jia & G. Liu. Controlled Molecular Assembly of Tetrazine Derivatives on Surfaces. (2021). CCS Chem.
(2021) CCS Chem.
Dispensing & Nanoprinting
M. Li, L. Liu & T. Zambelli. FluidFM for single-cell biophysics. (2021). Nano Research. doi: 10.1007/s12274-021-3573-y
FluidFM for single-cell biophysics
(2021) Nano Research.
Injection & Sampling
Pick & Place
Y. Cui, X. Lyu, L. Ding, L. Ke, D. Yang, M. Pirouz, Y. Qi, J. Ong, G. Gao, P. Du & R.I. Gregory.
Global miRNA dosage control of embryonic germ layer specification.
(2021) Nature.
Injection & Sampling
N. Chala, S. Moimas, C. Giampietro, X. Zhang, T. Zambelli, V. Exarchos, T.Z. Nazari-Shafti, D. Poulikakos & A. Ferrari.
Mechanical Fingerprint of Senescence in Endothelial Cells.
(2021) Nano Letters.
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Y. Guo, F. Mei, Y. Huang, S. Ma, Y. Wei, X. Zhang, M. Xu, Y. He, B.C. Heng, L. Chen & X. Deng.
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
(2021) Bioactive Materials.
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M. Koehler, S.J.L. Petitjean, J. Yang, P. Aravamudhan, X. Somoulay, C. Lo Giudice, M. A. Poncin, A.C. Dumitru, T.S. Dermody & D. Alsteens.
Reovirus directuly enganges integrin to recruit clathrin for entry into host cells.
(2021) Nature communications, 12, 2149.
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M. Mathelié-Guinlet, F. Viela, J. Dehullu, S. Filimova, J.M. Rauceo, P.N. Lipke & Y.F. Dufrêne.
Single-cell fluidic force microscopy reveals stress-dependent molecular interactions in yeast mating.
(2021) Commun Biol.
Pick & Place
2020
P. Saha, T. Duanis-Assaf & M. Reches. Fundamentals and Applications of FluidFM Technology in Single-Cell Studies. (2020) Advanced Materials Interfaces.
Pick & Place
Injection & Sampling
Dispensing & Nanoprinting
A. Saftics, B. Türk, A. Sulyok, N. Nagy, T. Gerecsei, I. Szekacs, S. Kurunczi & R. Horvath . Biomimetic dextran-based hydrogel layers for cell micropatterning over large areas using the FluidFM BOT technology. (2019) Langmuir, acs.langmuir.8b03249.
Dispensing & Nanoprinting
J. Zhang, H. Yu, B. Harris, Y. Zheng, U. Celik, L. Na, R. Faller, X. Chen, D. R. Haudenschild, G. Liu. New Means to Control Molecular Assembly (2020) ACS Publications.
Dispensing & Nanoprinting
L. Hofherr, C. Müller-Renno, C. Ziegler. FluidFM as a tool to study adhesion forces of bacteria - Optimization of parameters and comparison to conventional bacterial probe Scanning Force Spectroscopy. (2020). PLOS ONE.
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A.G. Nagy, A. Bonyár, I. Székács & R. Horvath. Analysis of single-cell force-spectroscopy data of Vero cells recorded by FluidFM BOT. (2020) IEEE 26th International Symposium for Design and Technology in Electronic Packaging (SIITME).
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I. Demir, J. Blockx, E. Dague, P. Guiraud, W. Thielmans, K. Muylaert & C. Formosa-Dague. Nanoscale Evidence Unravels Microalgae Flocculation Mechanism Induced by Chitosan. (2020) ACS Applied Biomaterials.
Pick & Place
I. Lüchtefeld, A. Bartolozzi, J. Mejía Morales, O. Dobre, M. Basso, T. Zambelli & M. Vassalli. Elasticity spectra as a tool to investigate actin cortex mechanics. (2020) Journal of Nanobiotechnology.
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P. Wysotzki, A. Sancho, J. Gimsa, J. Groll. A comparative analysis of detachment forces and energies in initial and mature cell-material interaction (2020) Science Direct.
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M. Sztilkovics, T. Gerecsei, B. Peter, A. Saftics, S. Kurunczi, I. Szekacs, B. Szabo & R. Horvath. Single-cell adhesion force kinetics of cell populations from combined label-free optical biosensor and robotic fluidic force microscopy. (2020) Scientific Reports.
Pick & Place
T. Schlotter, S. Weaver, C. Forró, D. Momotenko, J. Voros, T. Zambelli & M. Aramesh. Force-Controlled formation of dynamic nanopores for single-biomolecule sensing and single-cell secretomics. (2020) ACS Nano.
Others
T. Schlotter, S. Weaver, T. Zambelli, J. Voros & M. Aramesh. Force-controlled nanopores for single cell measurements using micro-channelled AFM Cantilevers. (2020). Biophysical Journal.
Others
2019
A. Mark, N. Helfricht, A. Rauh, J. Xue, P. Knödler, T. Schumacher, M. Karg, B. Du, M. Lippitz & G. Papastavrou. Electrokinetics in Micro-channeled Cantilevers: Extending the Toolbox for Reversible Colloidal Probes and AFM-based Nanofluidics. (2019). Scientific Reports.
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J. Dehullu, J.A. Vorholt, P.N. Lipke & Y.F. Dufrêne. Fluidic Force Microscopy Captures Amyloid Bonds between Microbial Cells. (2019). Trends in Microbiology.
Pick & Place
K. Doll, I. Yang, E. Fadeeva, N. Kommerein, S. P. Szafranski, G. B. der Wieden, A. Greuling, A. Winkel, B. N. Chichkov, N. S. Stumpp & M. Stiesch. Liquid-infused structured titanium surfaces: Antiadhesive mechanism to repel Streptococcus oralis biofilms. (2019) ACS Appl. Mater. Interfaces.
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J. Dehullu, C. Valotteau, P. Herman-Bausier, M. Garcia-Sherman, M. Mittelviefhaus, J.A. Vorholt, P.N. Lipke & Y.F. Dufrêne. Fluidic Force Microscopy Demonstrates that Homophilic Adhesion by Candida albicans Als Proteins is Mediated by Amyloid Bonds between Cells. (2019) Nano Letters.
Pick & Place
M. Mittelviefhaus. Bacterial Adaptations to Life on Surfaces: Single-Cell Adhesion and Type VI Secretion System Mediated Antagonism in Plant-Associated Bacteria. (Thesis) (2019) ETH Zurich.
Pick & Place
M. Mittelviehfhaus, D.B. Müller, T. Zambelli & J.A. Vorholt. A modular atomic force microscopy approach reveals a large range of hydrophobic adhesion forces among bacterial members of the leaf microbiota. (2019) The ISME Journal.
Pick & Place
M. Ryma, J. Blöhbaum, R. Singh, A. Sancho, J. Matuszak, I. Cicha & J. Groll. Easy-to-Prepare Coating of Standard Cell Culture Dishes for Cell-Sheet Engineering Using Aqueous Solutions of Poly(2-n-propyl-oxazoline). (2019) ACS Biomaterials Science and Engineering, 5(3), 1509-1517.
Pick & Place
D. Nahm, F. Weigl, N. Schaefer, A. Sancho, A. Frank, J. Groll, C. Villmann, H.W. Schmidt, P. Dalton, R. Luxenhofer. A versatile biomaterial ink platform for the melt electro writing of chemically-crosslinked hydrogels. (2019) Materials Horizon.
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A. Garitano-Trojaola, A. Sancho, R. Goetz, S. Walz, H. Jetani, E. Teufel, N. Rodhes, M. DaVia, L. Haertle, S. Nerreter, C. Vogt, J. Duell, R. Tibes, S. Kraus, A. Rosenwald, L. Rasche, M. Hudecek, M. Sauer, H. Einsele, J. Groll & M. Kortüm. RAC1 Inhibitor EHT1864 and Venetoclax overcome Midostaurin resistance in Acute Myeloid Leukemia. (2019). Blood.
Pick & Place
A. Mark, N. Helfricht, A. Rauh, M. Karg & G. Papastavrou. The Next Generation of Colloidal Probes: A Universal Approach for Soft and Ultra‐Small Particles. (2019) Small.
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M. Mathelié-Guinlet, F. Viela, A. Vijloen, J. Dehullu & Y.F. Dufrêne. Single-molecule atomic force microscopy studies of microbial pathogens. (2019) Current Opinion in Biomedical Engineering.
Pick & Place
T. Gerecsei, I. Erdödi, B. Peter, C. Hös, S. Kurunczi, I. Derényi, B. Szabo & R. Horvath. Adhesion force measurements on functionalized microbeads: an in-depth comparison of computer controlled micropipette and fluidic force microscopy. (2019) Journal of Colloid and Interface Science.
Pick & Place
Á.G. Nagy, J. Kámán, R. Horváth & A. Bonyár. Spring constant and sensitivity calibration of FluidFM micropipette cantilevers for force spectroscopy measurements. (2019) Scientific Reports, 9: 10287.
Pick & Place
P. Saha, T. Duanis-Assaf & M. Reches. Fundamentals and Applications of FluidFM Technology in Single-Cell Studies. (2020) Advanced Materials Interfaces.
Dispensing & Nanoprinting
M. Aramesh, C. Forró, L. Dorwling-Carter, I. Lüchtefeld, T. Schlotter, S.J. Ihle, I. Shorubalko, V. Hosseini, D. Momotenko, T. Zambelli, E. Klotzsch & J. Vörös. Localized detection of ions and biomolecules with a force-controlled scanning nanopore microscope. (2019) Nature Nanotechnology.
Others
A. Meller. A new tool for cell signalling research. (2019) Nature Nanotechnology.
Others
2018
H. M. Grandin, O. Guillaume-Gentil, T. Zambelli, M. Mayer, J. Houghtaling, C. G. Palivan, M. Textor, & F. Höök. Bioinspired, nanoscale approaches in contemporary bioanalytics (Review). (2018) Biointerphases 13, 040801.
Pick & Place
Injection & Sampling
Dispensing & Nanoprinting
M. Y. Amarouch, J. E. Hilaly & D. Mazouzi. AFM and FluidFM Technologies: Recent Applications in Molecular and Cellular Biology. Scanning, Volume 2018, Article ID 7801274, 10 pages.
Pick & Place
Injection & Sampling
Dispensing & Nanoprinting
P. Frederix, P. Werten & D. Yablon. FluidFM: Precise fluidic positioning and delivery platform with applications in cell biology and soft matter. (2018) Microscopy and Analysis, John Wiley & Sons Ltd.
Pick & Place
Injection & Sampling
Dispensing & Nanoprinting
O. Guillaume-Gentil, M. Mittelviefhaus, L. Dorwling-Carter, T. Zambelli & J. A. Vorholt. FluidFM Applications in Single-Cell Biology. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Implementations, Applications (Chapter 15), 2018, Wiley-VCH Verlag GmbH & Co.
Pick & Place
Injection & Sampling
Dispensing & Nanoprinting
P. Roder. Combination of fluorescence microscopy and atomic force microscopy for the investigation of physiological processes in living cells. (Thesis) (2018) Universität Potsdam.
Injection & Sampling
Dispensing & Nanoprinting
Y. Wei & Q. Xu. A Survey of Force-Assisted Robotic Cell Microinjection Technologies. (2018) IEEE Transactions on Automation Science and Engineering, 1-15.
Injection & Sampling
J. Zhang, V. A. Piunova, Y. Liu, A. Tek, Q. Yang, J. Frommer , G.-Y. Liu, & J. Sly. Controlled Molecular Assembly via Dynamic Confinement of Solvent. (2018) The Journal Of Physical Chemistry Letters, 9, 6232 - 6237.
Dispensing & Nanoprinting
S. Mishra, Y. Lee & J. W. Park. Direct quantification of trace amounts of a chronic myeloid leukemia biomarker using locked nucleic acid capture probes. (2018) Analytical Chemistry.
Dispensing & Nanoprinting
W. N. Deng, S. Wang, J. Ventrici de Souza, T. L. Kuhl & G.-Y. Liu. New Algorithm to Enable Construction and Display of 3D Structures from Scanning Probe Microscopy Images Acquired Layer-by-Layer. The Journal of Physical Chemistry A, 122(26), 5756-5763.
Dispensing & Nanoprinting
T. Zambelli, M. J. Aebersold, P. Behr, H. Han, L. Hirt, V. Martinez, O. Guillaume-Gentil & J. Vörös. FluidFM: Development of the Instrument as well as Its Applications for 2D and 3D Lithography. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Implementations, Applications (Chapter 14), 2018, Wiley-VCH Verlag GmbH & Co.Factsheet
Dispensing & Nanoprinting
P. Roder & C. Hille. Local tissue manipulation via a force- and pressure-controlled AFM micropipette for analysis of cellular processes. (2018) Scientific Reports 8:5892.
Dispensing & Nanoprinting
D. Huber, A. Oskooei, X. Casadevall I Solvas, A. deMello & G. V. Kaigala. Hydrodynamics in Cell Studies. (2018) Chemical reviews, 118, 2042-2079.
Dispensing & Nanoprinting
2017
S. G. Higgins, M. M. Stevens. Extracting the contents of living cells – Alumnia “nanostraws” enable longitudinal intracellular monitoring of live cells. (April 2017) Science, 356(6336).
Injection & Sampling
O. Guillaume-Gentil, T. Rey, P. Kiefer, A.J. Ibáñez, R. Steinhoff, R. Brönnimann, L. Dorwling-Carter, T. Zambelli, R. Zenobi & J.A. Vorholt. Single-Cell Mass Spectrometry of Metabolites Extracted from Live Cells by Fluidic Force Microscopy. (May 2017) Anal Chem., 89(9), 5017-5023.
Injection & Sampling
N. Cohen, S. Sarkar, E. Hondroulis, P. Sabhachandani & T. Konry. Quantification of intercellular adhesion forces measured by fluid force microscopy. (Nov 2017) Talanta, 174(1), 409-413.
Pick & Place
N. Helfricht, A. Mark, L. Dorwling-Carter, T. Zambelli and G. Papastavrou. Extending the Limits of Direct Force Measurements: Colloidal Probes from Sub – Micron Particles. Nanoscale.
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A. Sancho, I. Vandersmissen, S. Craps, A. Luttun, & J. Groll. A new strategy to measure intercellular adhesion forces in mature cell-cell contacts. (April 2017) Scientific Reports, 7(46152)
Pick & Place
L. Jaatinen. The Effect of an Applied Electric Current on Cell Proliferation, Viability, Morphology, Adhesion, and Stem Cell Differentiation. (Thesis) (2017) Tampere: Tampere University of Technology.
Pick & Place
K. S. Sprecher, I. Hug, J. Nesper,E. Potthoff, M. A. Mahi, M. Sangermani, V. Kaever, T. Schwede, J. Vorholt, U. Jenal. Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. (2017) mBio (American Society for Miobiology) 8(2).
Pick & Place
S. Sankaran, L. Jaatinen, J. Brinkmann, T. Zambelli, J. Vörös & P. Jonkheijm. Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy. (Apr 2017) ACS Nano., 11(4), 3867-3874.
Pick & Place
J.V. de Souza, Y. Liu, S. Wang, P. Dörig, T. L. Kuhl, J. Frommer & G.-Y. Liu. Three-Dimensional Nanoprinting via Direct Delivery. The Journal Of Physical Chemistry B.
Dispensing & Nanoprinting
M. J. Aebersold, H. Dermutz, L. Demkó, J. F. Saenz Cogollo, S.-C. Lin, C. Burchert, M. Schneider, D. Ling, C. Forró, H. Han, T. Zambelli & J. Vörös. Local Chemical Stimulation of Neurons with the Fluidic Force Microscope (FluidFM). (Nov 2017) ChemPhysChem, 1439-7641.
Dispensing & Nanoprinting
N. Helfricht, A. Mark, M. Behr, A. Bernet, H.W. Schmidt & G. Papastavrou. Writing with Fluid: Structuring Hydrogels with Micrometer Precision by AFM in Combination with Nanofluidics. (Aug 2017) Small, 13(31).
Dispensing & Nanoprinting
L. Hirt, A. Reiser, R. Spolenak & T. Zambelli. Additive Manufacturing of Metal Structures at the Micrometer Scale. Advanced Materials, 29(17).
Dispensing & Nanoprinting
2016
D. Ossola, P. Dörig, J. Vörös, T. Zambelli & M. Vassalli. Serial weighting of micro-objects with resonant microchanneled cantilevers. (Oct 2016) Nanotechnology, 27(41), 415502.
Pick & Place
N. Helfricht, E. Doblhofer, J. F.L. Duval, T. Scheibel & G. Papastavrou. Colloidal Properties of Recombinant Spider Silk Protein Particles. Journal of Physical Chemistry C, 120(32)
Pick & Place
J.S. McGrath, J. Quist, J.R.T. Seddon, S.C.S. Lai, S.G. Lemay & H.L. Bridle. Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe. PLOS ONE, 11(3), e0150438.
Pick & Place
L. Jaatinen, E. Young, J. Hyttinen, J. Vörös, T. Zambelli & L. Demkó. Quantifying the effect of electric current on cell adhesion studied by single-cell force spectroscopy. Biointerphases, 11(1), 011004.
Pick & Place
O. Guillaume-Gentil, R.V. Grindberg, R. Kooger, L. Dorwling-Carter, V. Martinez, D. Ossola, M. Pilhofer, T. Zambelli & J.A. Vorholt. Tunable Single-Cell Extraction for Molecular Analyses. (Jul 2016) Cell, 166(2), 506-516.
Injection & Sampling
H. Koo, I. Park, Y. Lee, H.J. Kim, J.H. Jung, J.H. Lee, Y. Kim, J.-H. Kim & J.W. Park. Visualization and Quantification of MicroRNA in a Single Cell Using Atomic Force Microscopy. Journal of the American Chemical Society, jacs.6b05048.
Dispensing & Nanoprinting
Y. Lee, Y. Kim, D. Lee, D. Roy & J.W. Park. Quantification of Fewer Than Ten Copies of a DNA Biomarker without Amplification or Labeling. Journal of the American Chemical Society, jacs.6b02791.
Dispensing & Nanoprinting
L. Hirt, S. Ihle, Z. Pan, L. Dorwling-Carter, A. Reiser, J.M. Wheeler, R. Spolenak, J. Vörös & T. Zambelli. Template-Free 3D Microprinting of Metals Using a Force-Controlled Nanopipette for Layer-by-Layer Electrodeposition. Advanced materials.
Dispensing & Nanoprinting
2015
P. Behr. FluidFM: Combining AFM with Micro-fluidics for Applications in Lifesciences and Multiparameter Surface Characterization. (Thesis) (2015) ETH Zurich.
Pick & Place
Dispensing & Nanoprinting
Injection & Sampling
E. Potthoff, D. Ossola, T. Zambelli & J.A. Vorholt. Bacterial adhesion force quantification by fluidic force microscopy. Nanoscale, 7(9), 4070 — 4079.
Pick & Place
B.R. Simona, L. Hirt, L. Demkó, T. Zambelli, J. Vörös, M. Ehrbar & V. Milleret. Density gradients at hydrogel interfaces for enhanced cell penetration. Biomater. Sci.
Pick & Place
P. Roder & C. Hille. A Multifunctional Frontloading Approach for Repeated Recycling of a Pressure-Controlled AFM Micropipette. PLOS ONE, 10(12), e0144157.
Dispensing & Nanoprinting
L. Hirt, R.R. Grüter, T. Berthelot, R. Cornut, J. Vörös & T. Zambelli. Local surface modification via confined electrochemical deposition with FluidFM. RSC Adv., 5(103), 84517 — 84522.
Dispensing & Nanoprinting
J. Geerlings, E. Sarajlic, E.J.W. Berenschot, R.G.P. Sanders, M.H. Siekman, L. Abelmann & N.R. Tas. Electric field controlled nanoscale contactless deposition using a nanofluidic scanning probe. Applied Physics Letters, 107(12), 123109.
Dispensing & Nanoprinting
R.R. Grüter, B. Dielacher, L. Hirt, J. Vörös & T. Zambelli. Patterning gold nanoparticles in liquid environment with high ionic strength for local fabrication of up to 100 µm long metallic interconnections. Nanotechnology, 26(17), 175301.
Dispensing & Nanoprinting
D. Ossola, L. Dorwling-Carter, H. Dermutz, P. Behr, J. Vörös & T. Zambelli. Simultaneous Scanning Ion Conductance Microscopy and Atomic Force Microscopy with Microchanneled Cantilevers. Physical Review Letters, 115(23), 238103.
Others
D. Ossola, M.-Y. Amarouch, P. Behr, J. Vörös, H. Abriel & T. Zambelli. Force-controlled patch clamp of beating cardiac cells. Nano letters, 15(3), 1743 — 50.
Others
2014
O. Guillaume-Gentil, E. Potthoff, D. Ossola, C.M. Franz, T. Zambelli & J.A. Vorholt. Force-controlled manipulation of single cells: From AFM to FluidFM. Trends in Biotechnology. Elsevier Ltd.
Pick & Place
Dispensing & Nanoprinting
Injection & Sampling
E. Potthoff, D. Franco, V.D'Alessandro, C. Starck, V. Falk, T. Zambelli, J.A. Vorholt, D. Poulikakos & A. Ferrari. Toward a rational design of surface textures promoting endothelialization. Nano Letters, 14(2), 1069 — 1079.
Pick & Place
Guillaume-Gentil, O., Zambelli, T., & Vorholt, J. A. (2014). Isolation of single mammalian cells from adherent cultures by fluidic force microscopy. Lab on a Chip, 14(2), 402–414.
Pick & Place
H. Dermutz, R.R. Grüter, A.M. Truong, L. Demkó, J. Vörös & T. Zambelli. Local polymer replacement for neuron patterning and in situ neurite guidance. Langmuir: the ACS journal of surfaces and colloids, 30(23), 7037 — 46.
Dispensing & Nanoprinting
J. Geerlings, E. Sarajlic, J.W. Berenschot, R.G.P. Sanders, L. Abelmann & N.R. Tas. Electrospray deposition from AFM probes with nanoscale apertures. In MEMS 2014 (pp. 100 — 103). San Francisco: IEEE.
Dispensing & Nanoprinting
2013
P. Dörig. Manipulating cells and colloids with FluidFM. (Thesis) (2013) ETH Zurich.
Pick & Place
Dispensing & Nanoprinting
Injection & Sampling
P. Stiefel, T. Zambelli & J.A. Vorholt. Isolation of optically targeted single bacteria by application of fluidic force microscopy to aerobic anoxygenic phototrophs from the phyllosphere. Applied and Environmental Microbiology, 79(16), 4895 — 4905.
Pick & Place
P. Dörig, D. Ossola, A.M. Truong, M. Graf, F. Stauffer, J. Vörös & T. Zambelli. Exchangeable colloidal AFM probes for the quantification of irreversible and long-term interactions. Biophysical Journal, 105(2), 463 — 472.
Pick & Place
O. Guillaume-Gentil, E. Potthoff, D. Ossola, P. Dörig, T. Zambelli & J.A. Vorholt. Force-controlled fluidic injection into single cell nuclei. Small, 9(11), 1904 — 1907.
Injection & Sampling
R.R. Grüter, J. Vörös & T. Zambelli. FluidFM as a lithography tool in liquid: spatially controlled deposition of fluorescent nanoparticles. Nanoscale, 5(3), 1097 — 104.
Dispensing & Nanoprinting
2012
E. Potthoff, O. Guillaume-Gentil, D. Ossola, J. Polesel-Maris, S. LeibundGut-Landmann, T. Zambelli & J.A. Vorholt. Rapid and Serial Quantification of Adhesion Forces of Yeast and Mammalian Cells. PLOS ONE, 7(12), e52712.
Pick & Place
P. Stiefel, F.I. Schmidt, P. Dörig, P. Behr, T. Zambelli, J.A. Vorholt & J. Mercer. Cooperative vaccinia infection demonstrated at the single-cell level using FluidFM. Nano Letters, 12(8), 4219 — 4227.
Dispensing & Nanoprinting2010
P. Dörig, P. Stiefel, P. Behr, E. Sarajlic, D. Bijl, M. Gabi, J. Vörös, J.A. Vorholt & T. Zambelli. Force-controlled spatial manipulation of viable mammalian cells and micro-organisms by means of FluidFM technology. Applied Physics Letters, 97(2), 023701 1 — 3.
Pick & Place
2009
A. Meister, M. Gabi, P. Behr, P. Studer, J. Vörös, P. Niedermann, J. Bitterli, J. Polesel - Maris, M. Liley, H. Heinzelmann & T. Zambelli. FluidFM: Combining atomic force microscopy and nanofluidics in an universal liquid delivery system for single cell applications and beyond. (2009) Nano Letters, 9 (6), 2501–2507.
Injection & Sampling
Dispensing & Nanoprinting
Meister, J. Polesel - Maris, P. Niedermann, J. Przybylska, P. Studer, M. Gabi, P. Behr, T. Zambelli, M. Liley, J. Vörös & H. Heinzelmann. Nanoscale dispensing in liquid environment of streptavidin on a biotin-functionalized surface using hollow atomic force microscopy probes. (2009) Microelectronic Engineering, 86(4-6), 1481 – 1484.
Dispensing & Nanoprinting2023
N. Chala, X. Zhang, T. Zambelli, Z. Zhang, T. Schneider, D. Panozzo, D. Poulikakos & A. Ferrari. 4D Force Detection of Cell Adhesion and Contractility. (2023) Nano Letters.
Pick & PlaceBattistella, A., Andolfi, L., Stebel, M., Ciubotaru, C., & Lazzarino, M. Investigation on the change of spermatozoa flagellar beating forces before and after capacitation. (2023) Biomaterials Advances, 145.
Pick & Place
M. Menetrey, C. van Nisselroy, M. Xu, J. Hengsteler, R. Spolenak &
T. Zambelli
. Microstructure-driven electrical conductivity optimization in additively manufactured microscale copper interconnects.
(2023) RSC Advances.
Pick & Place
2022
F. Weigl, C. Blum, A. Sancho & J. Groll. Correlative Analysis of Intra- versus Extracellular Cell Detachment Events vis the Alignment of Optical Imaging and Detachment Force Quantification. (2022). Adv. Mater. Technol.
Pick & Place
P.W. Doll, K. Doll, A. Winkel, R. Thelen, R. Ahrens, M. Stiesch & A.E. Guber. Influence of the Available Surface Area and Cell Elasticity on Bacterial Adhesion Forces on Highly Ordered Silicon Nanopillars. (2022). ACS Omega.
Pick & Place
A.G. Nagy, N. Kanyó, A. Vörös, I. Székács, A. Bonyár & R. Horvath. Population distributions of single-cell adhesion parameters during the cell cycle from high-throughput robotic fluidic force microscopy. (2022). Scientific Reports.
Pick & Place
F. Pan, M. Liu, S. Altenried, M. Lei, J. Yang, H. Straub, W.W. Schmal, K. Maniura-Weber, O. Guillaume-Gentil & Q. Ren. Uncoupling bacterial attachment on and detachment from polydimethylsiloxane surfaces though empirical and simulation studies. (2022). Journal of Colloid and Interface Science.
Pick & Place
C. Chien, J. Jiang, B. Gong, T. Li & A. Gaitas. AFM Microfluidic Cantilevers as Weight Sensors for Single Cell Mass Measurements. (2022). BioRxiv.
Pick & Place
Others
A. Sancho, M. B. Taskin, L. Wistlich, P. Stahlhut, K. Wittmann, A. Rossi & J. Groll. Cell Adhesion Assessment Reveals a Higher Force per Contact Area on Fibrous Structures Compared to Flat Surfaces. (2022). ACS Biomater. Sci. Eng.
Pick & Place
2021
A. Nagy, R. Horvath, A. Bonyár & M. Sztilkovics. A custom Software for the Evaluation of Single-Cell Force-Spectroscopy Data Acquired by FluidFM BOT. (2021). IEEE Xplore.
Pick & Place
Others
M.I. Rahim, K. Doll. N.S. Stumpp, M. Eisenburger & M. Stiesch. Multilayered Adsorption of Commensal Microflora on Implant Surfaces: an Unconventional and Innovative Method to Prevent Bacterial Infections Associated with Biomaterials. (2021). Adv. Mater. Interfaces.
Pick & Place
G. Gunaratnam, J. Dudek, P. Jung, S. Becker, K. Jacobs, M. Bischoff & M. Hannig. Quantification of the Adhesion Strength of Candida albicans to Tooth Enamel. (2021). Microorganisms.
Pick & Place
M. Li, L. Liu & T. Zambelli. FluidFM for single-cell biophysics. (2021). Nano Research. doi: 10.1007/s12274-021-3573-y
FluidFM for single-cell biophysics
(2021) Nano Research.
Pick & Place
Injection & Sampling
W. Li, A. Sancho, W. Chung, Y. Vinik, J. Groll, Y. Zick, O. Medalia, A.D. Bershadsky & B. Geiger. Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates.
(2021) Journal of Cell Science.
Pick & Place
A. Garitano-Trojaola, A. Sancho, R. Goetz, P. Eiring, S. Walz, H. Jetani, J. Gil-Pulido, M. DaVia, E. Teufel, N. Rhodes, L. Haertle, E. Arellano-Viera, R. Tibes, A. Rosenwald, L. Rasche, M. Hudecek, M. Sauer, J. Groll, H. Einsele, S. Kraus & M. Kortüm. Actin cytoskeleton deregulaltion confers midostaurin resistance in FLT-3 mutant acute myeloid leukemia.
(2021) Communications Biology.
Pick & Place
N. Chala, S. Moimas, C. Giampietro, X. Zhang, T. Zambelli, V. Exarchos, T.Z. Nazari-Shafti, D. Poulikakos & A. Ferrari.
Mechanical Fingerprint of Senescence in Endothelial Cells.
(2021) Nano Letters.
Pick & Place
Y. Guo, F. Mei, Y. Huang, S. Ma, Y. Wei, X. Zhang, M. Xu, Y. He, B.C. Heng, L. Chen & X. Deng.
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
(2021) Bioactive Materials.
Pick & Place
M. Koehler, S.J.L. Petitjean, J. Yang, P. Aravamudhan, X. Somoulay, C. Lo Giudice, M. A. Poncin, A.C. Dumitru, T.S. Dermody & D. Alsteens.
Reovirus directuly enganges integrin to recruit clathrin for entry into host cells.
(2021) Nature communications, 12, 2149.
Pick & Place
M. Mathelié-Guinlet, F. Viela, J. Dehullu, S. Filimova, J.M. Rauceo, P.N. Lipke & Y.F. Dufrêne.
Single-cell fluidic force microscopy reveals stress-dependent molecular interactions in yeast mating.
(2021) Commun Biol.
Pick & Place
2020
P. Saha, T. Duanis-Assaf & M. Reches. Fundamentals and Applications of FluidFM Technology in Single-Cell Studies. (2020) Advanced Materials Interfaces.
Pick & Place
Injection & Sampling
Localized Dispensing
L. Hofherr, C. Müller-Renno, C. Ziegler. FluidFM as a tool to study adhesion forces of bacteria - Optimization of parameters and comparison to conventional bacterial probe Scanning Force Spectroscopy. (2020). PLOS ONE.
Pick & Place
A.G. Nagy, A. Bonyár, I. Székács & R. Horvath. Analysis of single-cell force-spectroscopy data of Vero cells recorded by FluidFM BOT. (2020) IEEE 26th International Symposium for Design and Technology in Electronic Packaging (SIITME).
Pick & Place
I. Demir, J. Blockx, E. Dague, P. Guiraud, W. Thielmans, K. Muylaert & C. Formosa-Dague. Nanoscale Evidence Unravels Microalgae Flocculation Mechanism Induced by Chitosan. (2020) ACS Applied Biomaterials.
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I. Lüchtefeld, A. Bartolozzi, J. Mejía Morales, O. Dobre, M. Basso, T. Zambelli & M. Vassalli. Elasticity spectra as a tool to investigate actin cortex mechanics. (2020) Journal of Nanobiotechnology.
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P. Wysotzki, A. Sancho, J. Gimsa, J. Groll. A comparative analysis of detachment forces and energies in initial and mature cell-material interaction (2020) Science Direct.
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M. Sztilkovics, T. Gerecsei, B. Peter, A. Saftics, S. Kurunczi, I. Szekacs, B. Szabo & R. Horvath. Single-cell adhesion force kinetics of cell populations from combined label-free optical biosensor and robotic fluidic force microscopy. (2020) Scientific Reports.
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2019
A. Mark, N. Helfricht, A. Rauh, J. Xue, P. Knödler, T. Schumacher, M. Karg, B. Du, M. Lippitz & G. Papastavrou. Electrokinetics in Micro-channeled Cantilevers: Extending the Toolbox for Reversible Colloidal Probes and AFM-based Nanofluidics. (2019). Scientific Reports.
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J. Dehullu, J.A. Vorholt, P.N. Lipke & Y.F. Dufrêne. Fluidic Force Microscopy Captures Amyloid Bonds between Microbial Cells. (2019). Trends in Microbiology.
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K. Doll, I. Yang, E. Fadeeva, N. Kommerein, S. P. Szafranski, G. B. der Wieden, A. Greuling, A. Winkel, B. N. Chichkov, N. S. Stumpp & M. Stiesch. Liquid-infused structured titanium surfaces: Antiadhesive mechanism to repel Streptococcus oralis biofilms. (2019) ACS Appl. Mater. Interfaces.
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J. Dehullu, C. Valotteau, P. Herman-Bausier, M. Garcia-Sherman, M. Mittelviefhaus, J.A. Vorholt, P.N. Lipke & Y.F. Dufrêne. Fluidic Force Microscopy Demonstrates that Homophilic Adhesion by Candida albicans Als Proteins is Mediated by Amyloid Bonds between Cells. (2019) Nano Letters.
Pick & Place
M. Mittelviefhaus. Bacterial Adaptations to Life on Surfaces: Single-Cell Adhesion and Type VI Secretion System Mediated Antagonism in Plant-Associated Bacteria. (Thesis) (2019) ETH Zurich.
Pick & Place
M. Mittelviehfhaus, D.B. Müller, T. Zambelli & J.A. Vorholt. A modular atomic force microscopy approach reveals a large range of hydrophobic adhesion forces among bacterial members of the leaf microbiota. (2019) The ISME Journal.
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M. Ryma, J. Blöhbaum, R. Singh, A. Sancho, J. Matuszak, I. Cicha & J. Groll. Easy-to-Prepare Coating of Standard Cell Culture Dishes for Cell-Sheet Engineering Using Aqueous Solutions of Poly(2-n-propyl-oxazoline). (2019) ACS Biomaterials Science and Engineering, 5(3), 1509-1517.
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D. Nahm, F. Weigl, N. Schaefer, A. Sancho, A. Frank, J. Groll, C. Villmann, H.W. Schmidt, P. Dalton, R. Luxenhofer. A versatile biomaterial ink platform for the melt electro writing of chemically-crosslinked hydrogels. (2019) Materials Horizon.
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A. Garitano-Trojaola, A. Sancho, R. Goetz, S. Walz, H. Jetani, E. Teufel, N. Rodhes, M. DaVia, L. Haertle, S. Nerreter, C. Vogt, J. Duell, R. Tibes, S. Kraus, A. Rosenwald, L. Rasche, M. Hudecek, M. Sauer, H. Einsele, J. Groll & M. Kortüm. RAC1 Inhibitor EHT1864 and Venetoclax overcome Midostaurin resistance in Acute Myeloid Leukemia. (2019). Blood.
Pick & Place
A. Mark, N. Helfricht, A. Rauh, M. Karg & G. Papastavrou. The Next Generation of Colloidal Probes: A Universal Approach for Soft and Ultra‐Small Particles. (2019) Small.
Pick & Place
M. Mathelié-Guinlet, F. Viela, A. Vijloen, J. Dehullu & Y.F. Dufrêne. Single-molecule atomic force microscopy studies of microbial pathogens. (2019) Current Opinion in Biomedical Engineering.
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T. Gerecsei, I. Erdödi, B. Peter, C. Hös, S. Kurunczi, I. Derényi, B. Szabo & R. Horvath. Adhesion force measurements on functionalized microbeads: an in-depth comparison of computer controlled micropipette and fluidic force microscopy. (2019) Journal of Colloid and Interface Science.
Pick & Place
Á.G. Nagy, J. Kámán, R. Horváth & A. Bonyár. Spring constant and sensitivity calibration of FluidFM micropipette cantilevers for force spectroscopy measurements. (2019) Scientific Reports, 9: 10287.
Pick & Place
2018
H. M. Grandin, O. Guillaume-Gentil, T. Zambelli, M. Mayer, J. Houghtaling, C. G. Palivan, M. Textor, & F. Höök. Bioinspired, nanoscale approaches in contemporary bioanalytics (Review). (2018) Biointerphases 13, 040801.
Pick & Place
Injection & Sampling
Localized Dispensing
M. Y. Amarouch, J. E. Hilaly & D. Mazouzi. AFM and FluidFM Technologies: Recent Applications in Molecular and Cellular Biology. Scanning, Volume 2018, Article ID 7801274, 10 pages.
Pick & Place
Injection & Sampling
Localized Dispensing
P. Frederix, P. Werten & D. Yablon. FluidFM: Precise fluidic positioning and delivery platform with applications in cell biology and soft matter. (2018) Microscopy and Analysis, John Wiley & Sons Ltd.
Pick & Place
Injection & Sampling
Localized Dispensing
O. Guillaume-Gentil, M. Mittelviefhaus, L. Dorwling-Carter, T. Zambelli & J. A. Vorholt. FluidFM Applications in Single-Cell Biology. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Implementations, Applications (Chapter 15), 2018, Wiley-VCH Verlag GmbH & Co.
Pick & Place
Injection & Sampling
Localized Dispensing
2017
N. Cohen, S. Sarkar, E. Hondroulis, P. Sabhachandani & T. Konry. Quantification of intercellular adhesion forces measured by fluid force microscopy. (Nov 2017) Talanta, 174(1), 409-413.
Pick & Place
N. Helfricht, A. Mark, L. Dorwling-Carter, T. Zambelli and G. Papastavrou. Extending the Limits of Direct Force Measurements: Colloidal Probes from Sub – Micron Particles. Nanoscale.
Pick & Place
A. Sancho, I. Vandersmissen, S. Craps, A. Luttun, & J. Groll. A new strategy to measure intercellular adhesion forces in mature cell-cell contacts. (April 2017) Scientific Reports, 7(46152)
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L. Jaatinen. The Effect of an Applied Electric Current on Cell Proliferation, Viability, Morphology, Adhesion, and Stem Cell Differentiation. (Thesis) (2017) Tampere: Tampere University of Technology.
Pick & Place
K. S. Sprecher, I. Hug, J. Nesper,E. Potthoff, M. A. Mahi, M. Sangermani, V. Kaever, T. Schwede, J. Vorholt, U. Jenal. Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. (2017) mBio (American Society for Miobiology) 8(2).
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S. Sankaran, L. Jaatinen, J. Brinkmann, T. Zambelli, J. Vörös & P. Jonkheijm. Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy. (Apr 2017) ACS Nano., 11(4), 3867-3874.
Pick & Place
2016
D. Ossola, P. Dörig, J. Vörös, T. Zambelli & M. Vassalli. Serial weighting of micro-objects with resonant microchanneled cantilevers. (Oct 2016) Nanotechnology, 27(41), 415502.
Pick & Place
N. Helfricht, E. Doblhofer, J. F.L. Duval, T. Scheibel & G. Papastavrou. Colloidal Properties of Recombinant Spider Silk Protein Particles. Journal of Physical Chemistry C, 120(32)
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J.S. McGrath, J. Quist, J.R.T. Seddon, S.C.S. Lai, S.G. Lemay & H.L. Bridle. Deformability Assessment of Waterborne Protozoa Using a Microfluidic-Enabled Force Microscopy Probe. PLOS ONE, 11(3), e0150438.
Pick & Place
L. Jaatinen, E. Young, J. Hyttinen, J. Vörös, T. Zambelli & L. Demkó. Quantifying the effect of electric current on cell adhesion studied by single-cell force spectroscopy. Biointerphases, 11(1), 011004.
Pick & Place
2015
P. Behr. FluidFM: Combining AFM with Micro-fluidics for Applications in Lifesciences and Multiparameter Surface Characterization. (Thesis) (2015) ETH Zurich.
Pick & Place
Localized Dispensing
Injection & Sampling
E. Potthoff, D. Ossola, T. Zambelli & J.A. Vorholt. Bacterial adhesion force quantification by fluidic force microscopy. Nanoscale, 7(9), 4070 — 4079.
Pick & Place
B.R. Simona, L. Hirt, L. Demkó, T. Zambelli, J. Vörös, M. Ehrbar & V. Milleret. Density gradients at hydrogel interfaces for enhanced cell penetration. Biomater. Sci.
Pick & Place
2014
O. Guillaume-Gentil, E. Potthoff, D. Ossola, C.M. Franz, T. Zambelli & J.A. Vorholt. Force-controlled manipulation of single cells: From AFM to FluidFM. Trends in Biotechnology. Elsevier Ltd.
Pick & Place
Localized Dispensing
Injection & Sampling
E. Potthoff, D. Franco, V.D'Alessandro, C. Starck, V. Falk, T. Zambelli, J.A. Vorholt, D. Poulikakos & A. Ferrari. Toward a rational design of surface textures promoting endothelialization. Nano Letters, 14(2), 1069 — 1079.
Pick & Place
Guillaume-Gentil, O., Zambelli, T., & Vorholt, J. A. (2014). Isolation of single mammalian cells from adherent cultures by fluidic force microscopy. Lab on a Chip, 14(2), 402–414.
Pick & Place
2013
P. Dörig. Manipulating cells and colloids with FluidFM. (Thesis) (2013) ETH Zurich.
Pick & Place
Localized Dispensing
Injection & Sampling
P. Stiefel, T. Zambelli & J.A. Vorholt. Isolation of optically targeted single bacteria by application of fluidic force microscopy to aerobic anoxygenic phototrophs from the phyllosphere. Applied and Environmental Microbiology, 79(16), 4895 — 4905.
Pick & Place
P. Dörig, D. Ossola, A.M. Truong, M. Graf, F. Stauffer, J. Vörös & T. Zambelli. Exchangeable colloidal AFM probes for the quantification of irreversible and long-term interactions. Biophysical Journal, 105(2), 463 — 472.
Pick & Place
2012
E. Potthoff, O. Guillaume-Gentil, D. Ossola, J. Polesel-Maris, S. LeibundGut-Landmann, T. Zambelli & J.A. Vorholt. Rapid and Serial Quantification of Adhesion Forces of Yeast and Mammalian Cells. PLOS ONE, 7(12), e52712.
Pick & Place
2010
P. Dörig, P. Stiefel, P. Behr, E. Sarajlic, D. Bijl, M. Gabi, J. Vörös, J.A. Vorholt & T. Zambelli. Force-controlled spatial manipulation of viable mammalian cells and micro-organisms by means of FluidFM technology. Applied Physics Letters, 97(2), 023701 1 — 3.
Pick & Place
2024
Huang Y, Celik U, Xu Z, Speer D, Ossola D, Faller R, Parikh AN, Liu G-Y. (2024) Controlled Assembly of Lipid Molecules via Regulating Transient Spatial Confinement. Chemistry.
Dispensing & Nanoprinting Mulder, E. J., Moser, B., Delgado, J., Steinhardt, R. C., & Esser-Kahn, A. P. (2024). Evidence of collective influence in innate sensing using fluidic force microscopy. (2024) Frontiers in Immunology.
Dispensing & Nanoprinting
2022
C. Shen, Z. Zhu, D. Zhu, C. van Nisselroy, T. Zambelli & D. Momotenko. Electrochemical 3D printing of Ni-Mn and Ni-Co alloy with FluidFM. (2022). Nanotechnology.
Dispensing & Nanoprinting
2021
E. Berganza & M. Hirtz. Direct-Write Patterning of Biomimetic Lipid Membranes In Situ with FluidFM. (2021). ACS Appl. Mater. Interfaces.
Dispensing & Nanoprinting
I. Demi, I. Lüchtefeld, C. Lemen, E. Dague, P. Guiraud, T. Zambelli & C. Formosa-Dague. Probing the interactions between air bubbles and (bio)interfaces at the nanoscale using FluidFM technology. (2021). Journal of Colloid and Interface Science.
Dispensing & Nanoprinting
C. Müller-Renno, D. Remmel, M. Braun, K. Boonrod, G. Krczal & C. Ziegler. Producing plant virus patterns with defined 2D structure. (2021). PSS Applications and materials science.
Dispensing & Nanoprinting
S. Wang, S. Liu, A. Sulkanen, J.M. Fox, X. Jia & G. Liu. Controlled Molecular Assembly of Tetrazine Derivatives on Surfaces. (2021). CCS Chem.
(2021) CCS Chem.
Dispensing & Nanoprinting
2020
A. Saftics, B. Türk, A. Sulyok, N. Nagy, T. Gerecsei, I. Szekacs, S. Kurunczi & R. Horvath. Biomimetic dextran-based hydrogel layers for cell micropatterning over large areas using the FluidFM BOT technology. (2019) Langmuir, acs.langmuir.8b03249.
Dispensing & Nanoprinting
J. Zhang, H. Yu, B. Harris, Y. Zheng, U. Celik, L. Na, R. Faller, X. Chen, D. R. Haudenschild, G. Liu. New Means to Control Molecular Assembly (2020) ACS Publications.
Dispensing & Nanoprinting
2019
P. Saha, T. Duanis-Assaf & M. Reches. Fundamentals and Applications of FluidFM Technology in Single-Cell Studies. (2020) Advanced Materials Interfaces.
Dispensing & Nanoprinting
2018
P. Roder. Combination of fluorescence microscopy and atomic force microscopy for the investigation of physiological processes in living cells. (Thesis) (2018) Universität Potsdam.
Dispensing & Nanoprinting
Injection & Sampling
J. Zhang, V. A. Piunova, Y. Liu, A. Tek, Q. Yang, J. Frommer , G.-Y. Liu, & J. Sly. Controlled Molecular Assembly via Dynamic Confinement of Solvent. (2018) The Journal Of Physical Chemistry Letters, 9, 6232 - 6237.
Dispensing & Nanoprinting
S. Mishra, Y. Lee & J. W. Park. Direct quantification of trace amounts of a chronic myeloid leukemia biomarker using locked nucleic acid capture probes. (2018) Analytical Chemistry.
Dispensing & Nanoprinting
H. M. Grandin, O. Guillaume-Gentil, T. Zambelli, M. Mayer, J. Houghtaling, C. G. Palivan, M. Textor, & F. Höök. Bioinspired, nanoscale approaches in contemporary bioanalytics (Review). (2018) Biointerphases 13, 040801.
Dispensing & Nanoprinting
Injection & Sampling
Pick & Place
M. Y. Amarouch, J. E. Hilaly & D. Mazouzi. AFM and FluidFM Technologies: Recent Applications in Molecular and Cellular Biology. Scanning, Volume 2018, Article ID 7801274, 10 pages.
Dispensing & Nanoprinting
Injection & Sampling
Pick & Place
P. Frederix, P. Werten & D. Yablon. FluidFM: Precise fluidic positioning and delivery platform with applications in cell biology and soft matter. (2018) Microscopy and Analysis, John Wiley & Sons Ltd.
Injection & Sampling
Dispensing & Nanoprinting
Pick & Place
O. Guillaume-Gentil, M. Mittelviefhaus, L. Dorwling-Carter, T. Zambelli & J. A. Vorholt. FluidFM Applications in Single-Cell Biology. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Implementations, Applications (Chapter 15), 2018, Wiley-VCH Verlag GmbH & Co.
Injection & Sampling
Dispensing & Nanoprinting
Pick & Place
W. N. Deng, S. Wang, J. Ventrici de Souza, T. L. Kuhl & G.-Y. Liu. New Algorithm to Enable Construction and Display of 3D Structures from Scanning Probe Microscopy Images Acquired Layer-by-Layer. The Journal of Physical Chemistry A, 122(26), 5756-5763.
Dispensing & Nanoprinting
T. Zambelli, M. J. Aebersold, P. Behr, H. Han, L. Hirt, V. Martinez, O. Guillaume-Gentil & J. Vörös. FluidFM: Development of the Instrument as well as Its Applications for 2D and 3D Lithography. In: E. Delamarche, G. V. Kaigala. Open-Space Microfluidics: Concepts, Implementations, Applications (Chapter 14), 2018, Wiley-VCH Verlag GmbH & Co.Factsheet
Dispensing & Nanoprinting
P. Roder & C. Hille. Local tissue manipulation via a force- and pressure-controlled AFM micropipette for analysis of cellular processes. (2018) Scientific Reports 8:5892.
Dispensing & Nanoprinting
D. Huber, A. Oskooei, X. Casadevall I Solvas, A. deMello & G. V. Kaigala. Hydrodynamics in Cell Studies. (2018) Chemical reviews, 118, 2042-2079.
Dispensing & Nanoprinting
2017
J.V. de Souza, Y. Liu, S. Wang, P. Dörig, T. L. Kuhl, J. Frommer & G.-Y. Liu. Three-Dimensional Nanoprinting via Direct Delivery. The Journal Of Physical Chemistry B.
Dispensing & Nanoprinting
M. J. Aebersold, H. Dermutz, L. Demkó, J. F. Saenz Cogollo, S.-C. Lin, C. Burchert, M. Schneider, D. Ling, C. Forró, H. Han, T. Zambelli &J. Vörös. Local Chemical Stimulation of Neurons with the Fluidic Force Microscope (FluidFM). (Nov 2017) ChemPhysChem, 1439-7641.
Dispensing & Nanoprinting
N. Helfricht, A. Mark, M. Behr, A. Bernet, H.W. Schmidt & G. Papastavrou. Writing with Fluid: Structuring Hydrogels with Micrometer Precision by AFM in Combination with Nanofluidics. (Aug 2017) Small, 13(31).
Dispensing & Nanoprinting
L. Hirt, A. Reiser, R. Spolenak & T. Zambelli. Additive Manufacturing of Metal Structures at the Micrometer Scale. Advanced Materials, 29(17).
Dispensing & Nanoprinting
2016
H. Koo, I. Park, Y. Lee, H.J. Kim, J.H. Jung, J.H. Lee, Y. Kim, J.-H. Kim & J.W. Park. Visualization and Quantification of MicroRNA in a Single Cell Using Atomic Force Microscopy. Journal of the American Chemical Society, jacs.6b05048.
Dispensing & Nanoprinting
Y. Lee, Y. Kim, D. Lee, D. Roy & J.W. Park. Quantification of Fewer Than Ten Copies of a DNA Biomarker without Amplification or Labeling. Journal of the American Chemical Society, jacs.6b02791.
Dispensing & Nanoprinting
L. Hirt, S. Ihle, Z. Pan, L. Dorwling-Carter, A. Reiser, J.M. Wheeler, R. Spolenak, J. Vörös & T. Zambelli. Template-Free 3D Microprinting of Metals Using a Force-Controlled Nanopipette for Layer-by-Layer Electrodeposition. Advanced materials.
Dispensing & Nanoprinting
2015
P. Behr. FluidFM: Combining AFM with Micro-fluidics for Applications in Lifesciences and Multiparameter Surface Characterization. (Thesis) (2015) ETH Zurich.
Dispensing & Nanoprinting
Injection & Sampling
Pick & Place
P. Roder & C. Hille. A Multifunctional Frontloading Approach for Repeated Recycling of a Pressure-Controlled AFM Micropipette. PLOS ONE, 10(12), e0144157.
Dispensing & Nanoprinting
L. Hirt, R.R. Grüter, T. Berthelot, R. Cornut, J. Vörös & T. Zambelli. Local surface modification via confined electrochemical deposition with FluidFM. RSC Adv., 5(103), 84517 — 84522.
Dispensing & Nanoprinting
J. Geerlings, E. Sarajlic, E.J.W. Berenschot, R.G.P. Sanders, M.H. Siekman, L. Abelmann & N.R. Tas. Electric field controlled nanoscale contactless deposition using a nanofluidic scanning probe. Applied Physics Letters, 107(12), 123109.
Dispensing & Nanoprinting
R.R. Grüter, B. Dielacher, L. Hirt, J. Vörös & T. Zambelli. Patterning gold nanoparticles in liquid environment with high ionic strength for local fabrication of up to 100 µm long metallic interconnections. Nanotechnology, 26(17), 175301.
Dispensing & Nanoprinting
2014
O. Guillaume-Gentil, E. Potthoff, D. Ossola, C.M. Franz, T. Zambelli & J.A. Vorholt. Force-controlled manipulation of single cells: From AFM to FluidFM. Trends in Biotechnology. Elsevier Ltd.
Dispensing & Nanoprinting
Injection & Sampling
Pick & Place
H. Dermutz, R.R. Grüter, A.M. Truong, L. Demkó, J. Vörös & T. Zambelli. Local polymer replacement for neuron patterning and in situ neurite guidance. Langmuir: the ACS journal of surfaces and colloids, 30(23), 7037 — 46.
Dispensing & Nanoprinting
J. Geerlings, E. Sarajlic, J.W. Berenschot, R.G.P. Sanders, L. Abelmann & N.R. Tas. Electrospray deposition from AFM probes with nanoscale apertures. In MEMS 2014 (pp. 100 — 103). San Francisco: IEEE.
Dispensing & Nanoprinting
2013
P. Dörig. Manipulating cells and colloids with FluidFM. (Thesis) (2013) ETH Zurich.
Dispensing & Nanoprinting
Injection & Sampling
Pick & Place
R.R. Grüter, J. Vörös & T. Zambelli. FluidFM as a lithography tool in liquid: spatially controlled deposition of fluorescent nanoparticles. Nanoscale, 5(3), 1097 — 104.
Dispensing & Nanoprinting
2012
P. Stiefel, F.I. Schmidt, P. Dörig, P. Behr, T. Zambelli, J.A. Vorholt & J. Mercer. Cooperative vaccinia infection demonstrated at the single-cell level using FluidFM. Nano Letters, 12(8), 4219 — 4227.
Dispensing & Nanoprinting2009
A. Meister, M. Gabi, P. Behr, P. Studer, J. Vörös, P. Niedermann, J. Bitterli, J. Polesel - Maris, M. Liley, H. Heinzelmann & T. Zambelli. FluidFM: Combining atomic force microscopy and nanofluidics in an universal liquid delivery system for single cell applications and beyond. (2009) Nano Letters, 9 (6), 2501–2507.
Dispensing & Nanoprinting
Injection & Sampling
Meister, J. Polesel - Maris, P. Niedermann, J. Przybylska, P. Studer, M. Gabi, P. Behr, T. Zambelli, M. Liley, J. Vörös & H. Heinzelmann. Nanoscale dispensing in liquid environment of streptavidin on a biotin-functionalized surface using hollow atomic force microscopy probes. (2009) Microelectronic Engineering, 86(4-6), 1481 – 1484.
Dispensing & Nanoprinting2024
Yang Y, Wen D, Lin F, Song X, Pang R, Sun W, Yu D, Zhang Z, Yu T, Kong J, Zhang L, Cao X, Liao W, Wang D, Yang Q, Liang J, Zhang N, Li K, Xiong C, Liu Y. (2024) Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors. Science Advances.
OthersLiu X, Min Q, Cheng X, Zhang W, Wu Q, Chen X, Lv M, Liu S, Zhao H, Yang D, Tai Y, Lei X, Wang Y, Zhan Q. (2024) Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits. British Journal of Cancer.
OthersYan G, Li Y, Wang H, Cui S, Li Y, Zhang L, Yan J. Multiscale approach to the characterization of the interfacial properties of micellar casein and whey protein blends and their effects on recombined dairy creams. (2024) Food Research International.
OthersZhang X, Burattini M, Duru J, Chala N, Wyssen N, Cofiño-Fabres C, Rivera-Arbeláez JM, Passier R, Poulikakos D, Ferrari A, Tringides C, Vörös J, Luciani GB, Miragoli M, Zambelli T. Multimodal Mapping of Electrical and Mechanical Latency of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Layers. (2024) ACS Nano.
OthersLüchtefeld I, Pivkin IV, Gardini L, Zare-Eelanjegh E, Gäbelein C, Ihle SJ, Reichmuth AM, Capitanio M, Martinac B, Zambelli T, Vassalli M. Dissecting cell membrane tension dynamics and its effect on Piezo1-mediated cellular mechanosensitivity using force-controlled nanopipettes. (2024). Nature Methods.
OthersWang X, Xu H, Ning F, Duan S, Hu Y, Ding X, Xu FJ. Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films. (2024) Macromolecular Rapid Communications.
OthersMüller-Renno C, Ziegler C. The Contribution of Scanning Force Microscopy on Dental Research: A Narrative Review. (2024). Materials.
OthersBuisson, J., Zhang, X., Zambelli, T., Lavalle, P., Vautier, D., & Rabineau, M. Reverse Mechanotransduction: Driving Chromatin Compaction to Decompaction Increases Cell Adhesion Strength and Contractility. (2024) Nano Letters.
OthersGunaratnam, G., Leisering, R., Wieland, B., Dudek, J., Miosge, N., Becker, S. L., ... & Jung, P. Characterization of a unique attachment organelle: Single-cell force spectroscopy of Giardia duodenalis trophozoites. (2024) Nanoscale.
OthersTufoni, C., Battistella, A., Luppi, S., Boscolo, R., Ricci, G., Lazzarino, M., & Andolfi, L. Flagellar beating forces of human spermatozoa with different motility behaviors. (2024) Reproductive Biology and Endocrinology.
OthersBonyár, A., Nagy, Á. G., Gunstheimer, H., Fläschner, G., & Horvath, R. Hydrodynamic function and spring constant calibration of FluidFM micropipette cantilevers. (2024) Microsystems & Nanoengineering.
OthersHabli, Z., Lahoud, R., Zantout, A., Abou-Kheir, W., & Khraiche, M. L. Single-cell fluid-based force spectroscopy reveals near lipid size nano-topography effects on neural cell adhesion. (2024) Lab on a Chip.
Others2023
Z. Yang, X. Zhang, H. Li, B. Zhu, K. Feng and R. Wang, Impact of Dynamic Tip-Surface Interactions on Microdroplet Formation via Fluid Force Microscopy, (2023) IEEE Transactions on Nanotechnology.
OthersXiaoxuan Zhang, Martin Fussenegger, Structural materials meet synthetic biology in biomedical applications, (2023) Materials Today.
OthersRosales, Abigail Burato Causserand, Christel Coetsier, Clémence, Formosa-Dague, Cécile, Probing the reduction of adhesion forces between biofilms and anti-biofouling filtration membrane surfaces using FluidFM technology, (2023) Colloids and Surfaces B: Biointerfaces.
OthersXu, H., Duan, S., Hu, Y., Ding, X., & Xu, F.-J. Rapid Regulation of Cardiomyocytes Adhesion on Substrates with Varied Modulus via Mechanical Cues. (2023) Biomacromolecules.
Others
2022
C. Chien, J. Jiang, B. Gong, T. Li & A. Gaitas. AFM Microfluidic Cantilevers as Weight Sensors for Single Cell Mass Measurements. (2022). BioRxiv.
Others2021
A. Nagy, R. Horvath, A. Bonyár & M. Sztilkovics. A custom Software for the Evaluation of Single-Cell Force-Spectroscopy Data Acquired by FluidFM BOT. (2021). IEEE Xplore.
Pick & Place
Others
Y. Qiu, C. Chien, B. Maroulis, A. Gaitas & B. Gong. Extending applications of AFM to fluidic AFM in single living cell and extracellular vesicle studies. (2021). Research Square.
Others
J. Yang, J. Park, M. Koehler, J. Simpson, D. Luque, J.M. Rodriguez & D. Alsteens. Rotavirus Binding to Cell Surface Receptors Directly recruiting a-integrin. (2021). Advanced Nanobiomed Research.
Others
Á. Gábor Nagy, N. Pap, R. Horvath & A. Bonyár. Determination of the Resonance Frequency and Spring Constant of FluidFM Cantilevers with Numerical Simulations. (2021) ISSE.
Others
2020
T. Schlotter, S. Weaver, C. Forró, D. Momotenko, J. Voros, T. Zambelli & M. Aramesh. Force-Controlled formation of dynamic nanopores for single-biomolecule sensing and single-cell secretomics. (2020) ACS Nano.
Others
T. Schlotter, S. Weaver, T. Zambelli, J. Voros & M. Aramesh. Force-controlled nanopores for single cell measurements using micro-channelled AFM Cantilevers. (2020). Biophysical Journal.
Others
2019
M. Aramesh, C. Forró, L. Dorwling-Carter, I. Lüchtefeld, T. Schlotter, S.J. Ihle, I. Shorubalko, V. Hosseini, D. Momotenko, T. Zambelli, E. Klotzsch & J. Vörös. Localized detection of ions and biomolecules with a force-controlled scanning nanopore microscope. (2019) Nature Nanotechnology.
Others
A. Meller. A new tool for cell signalling research. (2019) Nature Nanotechnology.
Others
2018
L. Dorwling-Carter, M. Aramesh, C. Forró, R.F. Tiefenauer, I. Shorubalko, J. Vörös & T. Zambelli. Simultaneous scanning ion conductance and atomic force microscopy with a nanopore: Effect of the aperture edge on the ion current images. (2018) Journal of Applied Physics, 124(17), 174902.
Others
L. Dorwling-Carter, M. Aramesh, H. Han, T. Zambelli & D. Momotenko. Combined Ion Conductance and Atomic Force Microscope for Fast Simultaneous Topographical and Surface Charge Imaging. (2018) Analytical Chemistry, Just Accepted Manuscript.
Others
2015
D. Ossola, L. Dorwling-Carter, H. Dermutz, P. Behr, J. Vörös & T. Zambelli. Simultaneous Scanning Ion Conductance Microscopy and Atomic Force Microscopy with Microchanneled Cantilevers. Physical Review Letters, 115(23), 238103.
Others
D. Ossola, M.-Y. Amarouch, P. Behr, J. Vörös, H. Abriel & T. Zambelli. Force-controlled patch clamp of beating cardiac cells. Nano letters, 15(3), 1743 — 50.
Others
2013
P. Schön, J. Geerlings, N. Tas & E. Sarajlic. AFM Cantilever with in Situ Renewable Mercury Microelectrode. Analytical chemistry, 85(19), 8937 — 42.
Others
Dr. Pascal Behr
CEO
Pascal holds a doctoral degree from ETH Zurich. His passion for entrepreneurship and Startups has led him to the foundation of Cytosurge. He currently serves as CEO of the company and is responsible for all operational and strategic matters of the company.
When away from work, Pascal enjoys spending time at the Rhine river - in summer and in winter. He loves scuba diving and has a passion for the latest tech gadgets.
Management TeamFounders
Stephan Jud
CTO
Stephan is a software architect with over 14 years of experience. As one of the company's first employees he has a profound understanding of the FluidFM technology. In his role as CTO he leads the research and development of our solutions and is responsible for the direction, design and development of Cytosurge's products.
When the sun is shining, Stephan enjoys playing soccer. However, he takes far more pleasure in watching soccer matches from inside a stadion or from the comfort of his living room couch.
Management TeamResearch & Development
Dr. Pablo Dörig
HEAD OF CUSTOMER SUCCESS VP AFM SOLUTIONS BU
Pablo is a trained micro- and nanosystems engineer and won the ETH medal for his outstanding PhD thesis on FluidFM. With a good connection to our customers he brings invaluable experience into our team. In his position, Pablo ensures that our solutions fully meet our customers' needs and expectations.
To relax, he enjoys video games as well as long talks with his family and friends while sipping a glass of wine.
Management TeamResearch & Development
Dr. Pascal Behr
CEO
Pascal holds a doctoral degree from ETH Zurich. His passion for entrepreneurship and Startups has led him to the foundation of Cytosurge. He currently serves as CEO of the company and is responsible for all operational and strategic matters of the company.
When away from work, Pascal enjoys spending time at the Rhine river - in summer and in winter. He loves scuba diving and has a passion for the latest tech gadgets.
Management TeamFounders
Stephan Jud
CTO
Stephan is a software architect with over 14 years of experience. As one of the company's first employees he has a profound understanding of the FluidFM technology. In his role as CTO he leads the research and development of our solutions and is responsible for the direction, design and development of Cytosurge's products.
When the sun is shining, Stephan enjoys playing soccer. However, he takes far more pleasure in watching soccer matches from inside a stadion or from the comfort of his living room couch.
Management TeamResearch & Development
Dr. Pablo Dörig
HEAD OF CUSTOMER SUCCESS VP AFM SOLUTIONS BU
Pablo is a trained micro- and nanosystems engineer and won the ETH medal for his outstanding PhD thesis on FluidFM. With a good connection to our customers he brings invaluable experience into our team. In his position, Pablo ensures that our solutions fully meet our customers' needs and expectations.
To relax, he enjoys video games as well as long talks with his family and friends while sipping a glass of wine.
Management TeamResearch & Development
Dr. Pascal Behr
CEO
Pascal holds a doctoral degree from ETH Zurich. His passion for entrepreneurship and Startups has led him to the foundation of Cytosurge. He currently serves as CEO of the company and is responsible for all operational and strategic matters of the company.
When away from work, Pascal enjoys spending time at the Rhine river - in summer and in winter. He loves scuba diving and has a passion for the latest tech gadgets.
Management TeamFounders
Stephan Jud
CTO
Stephan is a software architect with over 14 years of experience. As one of the company's first employees he has a profound understanding of the FluidFM technology. In his role as CTO he leads the research and development of our solutions and is responsible for the direction, design and development of Cytosurge's products.
When the sun is shining, Stephan enjoys playing soccer. However, he takes far more pleasure in watching soccer matches from inside a stadion or from the comfort of his living room couch.
Management TeamResearch & Development
Dr. Pablo Dörig
HEAD OF CUSTOMER SUCCESS VP AFM SOLUTIONS BU
Pablo is a trained micro- and nanosystems engineer and won the ETH medal for his outstanding PhD thesis on FluidFM. With a good connection to our customers he brings invaluable experience into our team. In his position, Pablo ensures that our solutions fully meet our customers' needs and expectations.
To relax, he enjoys video games as well as long talks with his family and friends while sipping a glass of wine.
Management TeamResearch & Development